Topic 1 : Screening, Separation and Identification of Metal-Chelating Peptides in Complex Mixtures for Health and Nutrition Applications
These researches focus on the setting-up of original screening methods of antioxidant metal chelating peptides in a complex mixture, before launching long-time consuming separation steps. They involve:
> the screening methods using either Surface Plasmon Resonance or IMAC-MS;
> the modelling of data obtained at the molecular scale by SPR for predicting separation at the IMAC process scale (coll. Perseval Axis);
> the establishment of QSAR type correlations between the affinity of an immobilised metal ion and a peptide, and its antioxidant activity.
Topic 2: Separation of Phenolic Compounds in Bio-oil produced by Thermochemical Conversion of Lignocellulosic Biomass
These research activities led in collaboration with CITHERE
axis aim to use thermodynamic tools in order to improve the conditions of
Liquid/Liquid Extraction of phenolics contained in bio-oils and then, to
evaluate their antioxidant properties.
Topic 3: Identification of New Antioxidant Molecules in various Vegetal and Animal Ressources
Coll.: University of Constantine (Algeria), University of Gabès and the Institute of Applied Biology of Medenine (Tunisia), University of Antioquia (Médellin, Columbia)